O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Base Information

Chemical Name:O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine
CAS No.:1025965-55-2
Molecular Formula:C₂₆H₂₅FN₂O₂
Molecular Weight:416.495
Hs Code.:

<i>O</i>-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Synonyms:O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

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Chemical Property of O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Chemical Property:

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Technology Process of O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

There total 5 articles about O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025979-40-1
2-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butoxy}-isoindole-1,3-dione

: 1025965-55-2
O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Guidance literature:: With hydrazine hydrate; In ethanol; dichloromethane; for 0.5h; Heating;
DOI:10.1021/jm9904102

Reference yield:

: 3747-74-8
2-(chloromethyl)quinoline monohydrochloride

: 1025965-55-2
O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 12 h / 20 °C

3: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

With potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition / 3: Mitsunobu reaction / 4: Substitution;
DOI:10.1021/jm9904102

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1025965-55-2
O-{4-(4-fluoro-phenyl)-1-[4-(quinolin-2-ylmethoxy)-phenyl]-butyl}-hydroxylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / K₂CO₃ / dimethylformamide / 16 h / 20 °C

2: tetrahydrofuran / 12 h / 20 °C

3: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 14 h / 20 °C

4: hydrazine hydrate / ethanol; CH₂Cl₂ / 0.5 h / Heating

With potassium carbonate; hydrazine hydrate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Alkylation / 2: Addition / 3: Mitsunobu reaction / 4: Substitution;
DOI:10.1021/jm9904102