(E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea

Base Information

• Chemical Name: (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea
• CAS No.: 1579999-08-8
• Molecular Formula: C₃₂H₂₇F₉N₆O₂S
• Molecular Weight: 730.657
• Mol file: 1579999-08-8.mol

Synonyms:(E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea

Chemical Property of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea

There total 7 articles about (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

(E)-(5-((3-amino-5-(trifluoromethyl)phenyl)diazenyl)-1,3-phenylene)bis(pyrrolidin-1-ylmethanone) (1579999-01-1) + 3,5-bistrifluoromethylphenylisothiocyanate (23165-29-9) → (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea (1579999-08-8)

Guidance literature:

In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol500381c

Reference yield:

2-(3-amino-5-(trifluoromethyl)phenyl)isoindoline-1,3-dione (1610038-13-5) → (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea (1579999-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / 24 h / 20 °C

2: hydrazine hydrate / methanol / 10 h

3: dichloromethane / 20 °C / Inert atmosphere

With hydrazine hydrate; acetic acid; In methanol; dichloromethane;

DOI:10.1021/ol500381c

Reference yield:

5-aminoisophthalic acid (99-31-0) → (E)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea (1579999-08-8)

Guidance literature:

Multi-step reaction with 5 steps

1: N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / N,N-dimethyl-formamide; acetonitrile / 16 h / 20 °C / Inert atmosphere

2: Oxone / dichloromethane; water / 0.5 h / 20 °C / Inert atmosphere

3: acetic acid / 24 h / 20 °C

4: hydrazine hydrate / methanol / 10 h

5: dichloromethane / 20 °C / Inert atmosphere

With Oxone; hydrazine hydrate; acetic acid; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/ol500381c

upstream raw materials:

2-(3-amino-5-(trifluoromethyl)phenyl)isoindoline-1,3-dione

(E)-2-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)diazenyl)-5-(trifluoromethyl)phenyl)-isoindoline-1,3-dione

(E)-(5-((3-amino-5-(trifluoromethyl)phenyl)diazenyl)-1,3-phenylene)bis(pyrrolidin-1-ylmethanone)

3,5-bistrifluoromethylphenylisothiocyanate

Downstream raw materials:

(Z)-1-(3,5-bis(trifluoromethyl)phenyl)-3-(3-((3,5-di(pyrrolidine-1-carbonyl)phenyl)-diazenyl)-5-(trifluoromethyl)phenyl)thiourea