N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Base Information

• Chemical Name: N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide
• CAS No.: 1338815-58-9
• Molecular Formula: C₃₈H₄₆N₆O₅Si
• Molecular Weight: 694.906
• Mol file: 1338815-58-9.mol

Synonyms:N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Chemical Property of N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide

There total 1 articles about N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine (876301-36-9) + N-(4-((4-aminonaphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxy acetamide (1229607-39-9) + 1,1'-carbonyldiimidazole (530-62-1) → N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide (1338815-58-9)

Guidance literature:

3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 16h;

N-(4-((4-aminonaphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxy acetamide; In dichloromethane; at 20 ℃; for 2h;

Reference yield: 79.0%

N-(4-(4-(3-(3-tert-butyl-1-(4-(tert-butyldimethylsilyloxy)phenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-yl)-2-methoxyacetamide (1338815-58-9) → N-(4-((4-(3-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxyacetamide (1338814-53-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

upstream raw materials:

3-tert-butyl-1-(4-(tert-butyldimethyl-silyloxy)phenyl)-1H-pyrazol-5-amine

N-(4-((4-aminonaphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxy acetamide

1,1'-carbonyldiimidazole

Downstream raw materials:

N-(4-((4-(3-(3-(tert-butyl)-1-(4-hydroxyphenyl)-1H-pyrazol-5-yl)ureido)naphthalen-1-yl)oxy)pyridin-2-yl)-2-methoxyacetamide