Technology Process of Z-L-Glu(γBn)-D-His-OMe
There total 2 articles about Z-L-Glu(γBn)-D-His-OMe which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 0.5h;
Inert atmosphere;
(R)-histidine methyl ester dihydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/chir.22056
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: thionyl chloride / methanol / 16 h / 0 °C / Inert atmosphere; Reflux
2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
thionyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
methanol; N,N-dimethyl-formamide;
DOI:10.1002/chir.22056
