2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

Base Information

Chemical Name:2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide
CAS No.:99380-93-5
Molecular Formula:BrH*C₁₆H₂₂BrNO
Molecular Weight:405.173
Hs Code.:

Synonyms:2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

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Chemical Property of 2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

Chemical Property:

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Technology Process of 2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

There total 6 articles about 2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 99380-92-4
2-(2-hydroxyethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone

: 99380-93-5
2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

Guidance literature:: With hydrogen bromide; at 100 ℃; heating overnight;
DOI:10.1002/jhet.5570220312

Reference yield:

: 1198-34-1
2-Phenylcyclopentanone

: 99380-93-5
2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1: 70 percent / sodium amide / benzene / Ambient temperature; stirring overnight, than reflux 3 hrs.

2: 86 percent / p-toluenesulfonic acid / various solvent(s) / 5 h / 160 - 165 °C

3: 95 percent / LAH / diethyl ether; tetrahydrofuran / 15 h / Heating

4: 94 percent / pyridinium p-toluenesulfonate / acetone; H₂O / Heating

5: 69 percent / hydrochloric acid (conc.) / ethanol; H₂O / 4 h / Heating

6: 68 percent / hydrobromic acid (48 percent) / 100 °C / heating overnight

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; sodium amide; In tetrahydrofuran; diethyl ether; ethanol; water; acetone; benzene;
DOI:10.1002/jhet.5570220312

Reference yield:

: 2819-69-4
2-carbethoxymethyl-2-phenylcyclopentanone

: 99380-93-5
2-(2-bromoethyl)-5-(N,N-dimethylaminomethyl)-2-phenylcyclopentanone hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / p-toluenesulfonic acid / various solvent(s) / 5 h / 160 - 165 °C

2: 95 percent / LAH / diethyl ether; tetrahydrofuran / 15 h / Heating

3: 94 percent / pyridinium p-toluenesulfonate / acetone; H₂O / Heating

4: 69 percent / hydrochloric acid (conc.) / ethanol; H₂O / 4 h / Heating

5: 68 percent / hydrobromic acid (48 percent) / 100 °C / heating overnight

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen bromide; pyridinium p-toluenesulfonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; ethanol; water; acetone;
DOI:10.1002/jhet.5570220312