(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Base Information

Chemical Name:(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
CAS No.:191805-42-2
Molecular Formula:C₁₅H₁₉NO₂
Molecular Weight:245.321
Hs Code.:

Synonyms:(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Suppliers and Price of (2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

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Chemical Property of (2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

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Technology Process of (2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

There total 1 articles about (2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 37577-28-9,58550-13-3,757124-50-8
(1S,2R)-(+)-norphedrine

: 3128-06-1
5-ketohexanoic acid

: 191805-42-2
(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: In toluene; for 12h; Heating;
DOI:10.1016/S0040-4020(97)90391-4

Reference yield: 72.0%

: 191805-42-2
(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 191805-44-4
(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridine-5-thione

Guidance literature:: With 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In toluene; for 1h; Heating;
DOI:10.1016/S0040-4020(97)90391-4

Reference yield:

: 191805-42-2
(2S,3R,8aS)-3,8a-Dimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: (2S,3R,7R,8aS)-3,7,8a-Trimethyl-2-phenyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / Belleau's reagent / toluene / 1 h / Heating

2: 100 percent / CH₂Cl₂ / 1 h / Heating

3: CuI, I₂ / tetrahydrofuran / 12 h / Heating

4: 2,2,6,6-tetramethylpiperidine, n-BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide; hexane / 0.33 h / -78 °C

5: 0.12 g / HCl / tetrahydrofuran; H₂O / 6 h / Ambient temperature

With 2,2,6,6-tetramethyl-piperidine; hydrogenchloride; copper(l) iodide; n-butyllithium; iodine; 2,4-(4-phenoxyphenyl)-1,3-dithia-2λ(5),4λ(5)-diphosphetane 2,4-disulfides; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; water; toluene;
DOI:10.1016/S0040-4020(97)90391-4