1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Base Information

Chemical Name:1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione
CAS No.:1188542-43-9
Molecular Formula:C₃₂H₄₄F₃N₇O₃Si
Molecular Weight:659.827
Hs Code.:

1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Synonyms:1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

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Chemical Property of 1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

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Technology Process of 1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

There total 10 articles about 1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869788-45-4
1,3-dipropyl-8-(1H-pyrazol-4-yl)-7-(2-trimethylsilanylethoxymethyl)-3,7-dihydro-purine-2,6-dione

: 1188542-42-8
methanesulfonic acid 1-(3-trifluoromethylphenyl)pyrrolidin-3-ylmethyl ester

: 1188542-43-9
1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 75 - 80 ℃; for 16h;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 873841-00-0
1-benzyl-1H-pyrazole-4-carboxylic acid (6-amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-amide

: 1188542-43-9
1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / methanol / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 20 °C

3: palladium 10% on activated carbon; hydrogen / dichloromethane; methanol / 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007

Reference yield:

: 98-16-8
3-trifluoromethylaniline

: 1188542-43-9
1,3-dipropyl-8-{1-[1-(3-trifluoromethyl-phenyl)-pyrrolidin-3-ylmethyl]-1H-pyrazol-4-yl}-7-(2-trimethylsilanyl-ethoxymethyl)-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2.5 h / 120 - 130 °C / Sealed tube

1.2: 0.33 h / Sealed tube

2.1: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 22 h / 0 - 20 °C / Reflux

3.1: triethylamine / dichloromethane / 0.25 h / 0 °C

3.2: 1.5 h / 10 - 15 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 75 - 80 °C

With lithium aluminium tetrahydride; potassium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2016.11.007