[2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine

Base Information

• Chemical Name: [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine
• CAS No.: 263722-12-9
• Molecular Formula: C₂₃H₂₅NO₄
• Molecular Weight: 379.456
• Mol file: 263722-12-9.mol

Synonyms:[2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine

Chemical Property of [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine

There total 5 articles about [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2R,4R)-3-tert-butoxycarbonyl-2-(3-phenyl-prop-2-ynoil)-4-phenyl-1,3-oxazolidine (263722-10-7) → [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine (263722-12-9)

Guidance literature:

With zinc(II) tetrahydroborate; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1016/S0040-4020(99)00949-7

Reference yield:

phenylacetylene (536-74-3) → [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine (263722-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - -10 °C

2: 95 percent / Zn(BH₄)2 / diethyl ether / 1 h / 0 °C

With n-butyllithium; zinc(II) tetrahydroborate; In tetrahydrofuran; diethyl ether; hexane; 1: Substitution / 2: Reduction;

DOI:10.1016/S0040-4020(99)00949-7

Reference yield:

Weinreb amide (164530-43-2) → [2R,2(1S),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-ynyl)-4-phenyl-1,3-oxazolidine (263722-12-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / n-BuLi / tetrahydrofuran; hexane / 2 h / -78 - -10 °C

2: 95 percent / Zn(BH₄)2 / diethyl ether / 1 h / 0 °C

With n-butyllithium; zinc(II) tetrahydroborate; In tetrahydrofuran; diethyl ether; hexane; 1: Substitution / 2: Reduction;

DOI:10.1016/S0040-4020(99)00949-7

upstream raw materials:

(2R,4R)-3-tert-butoxycarbonyl-2-(3-phenyl-prop-2-ynoil)-4-phenyl-1,3-oxazolidine

Weinreb amide

lithium phenylacetylide

phenylacetylene

Downstream raw materials:

[2R,2(1S,2E),4R]-3-tert-butoxycarbonyl-2-(1-hydroxy-3-phenyl-prop-2-enyl)-4-phenyl-1,3-oxazolidine