7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

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Chemical Name:7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one
CAS No.:1285532-66-2
Molecular Formula:C₂₆H₂₄BrN₃O₄S
Molecular Weight:554.464
Hs Code.:

Synonyms:7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

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Chemical Property of 7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

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Technology Process of 7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

There total 12 articles about 7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1285532-82-2
(R)-7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1285532-66-2
7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 247174-15-8
6-bromo-2-tert-butyldimethylsilyloxy-1-methylnaphthalene

: 1285532-66-2
7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

Guidance literature:: Multi-step reaction with 9 steps

1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -70 °C

1.2: 0.83 h / -70 °C

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

3.1: pyridine / 1 h / 0 °C

4.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 21 h / Reflux

6.1: tetrahydrofuran; methanol / 1 h / 0 - 20 °C

7.1: pyridine hydrochloride / methanol; chloroform / 3 h / 60 °C

8.1: Chiralpak AD / ethanol; hexane / Resolution of racemate

9.1: N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; n-butyllithium; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; palladium diacetate; pyridine hydrochloride; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; hexane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017

Reference yield:

: 337521-09-2
1-(6-{[tert-butyl(dimethyl)silyl]oxy}-5-methyl-2-naphthyl)-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propan-1-ol

: 1285532-66-2
7-[(1R)-1-{1-[(4-bromophenyl)sulfonyl]-1H-imidazol-4-yl}-1-hydroxy-2-methylpropyl]-2-methyl-1,2-dihydro-3H-benzo[e]isoindol-3-one

Guidance literature:: Multi-step reaction with 8 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

2: pyridine / 1 h / 0 °C

3: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 14 h / 70 °C / 760.05 Torr

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 21 h / Reflux

5: tetrahydrofuran; methanol / 1 h / 0 - 20 °C

6: pyridine hydrochloride / methanol; chloroform / 3 h / 60 °C

7: Chiralpak AD / ethanol; hexane / Resolution of racemate

8: N,N-dimethyl-formamide / 3 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; palladium diacetate; pyridine hydrochloride; triethylamine; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; hexane; chloroform; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.01.017