(3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene

Base Information

• Chemical Name: (3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene
• CAS No.: 350985-90-9
• Molecular Formula: C₁₈H₁₇NO₆
• Molecular Weight: 343.336
• Mol file: 350985-90-9.mol

Synonyms:(3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene

Chemical Property of (3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene

There total 1 articles about (3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

(3R,5S)-5-acetoxy-1-ethynyl-3-hydroxy-2-methylcyclohex-1-ene (169437-98-3) + 4-nitro-benzoic acid (62-23-7) → (3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene (350985-90-9)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1021/jo010017f

Reference yield: 96.0%

(3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene (350985-90-9) → (3S,5S)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene (169437-96-1)

Guidance literature:

With sodium methylate; In methanol; at 0 ℃; for 2.5h;

DOI:10.1021/jo010017f

Reference yield:

(3S,5S)-5-acetoxy-1-ethynyl-2-methyl-3-[(4-nitrophenyl)carbonyloxy]cyclohex-1-ene (350985-90-9) → (3S,5S)-1-ethynyl-3-hydroxy-2-methyl-5-(phenoxycarbonyloxy)cyclohex-1-ene

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / MeONa / methanol / 2.5 h / 0 °C

2: 55 percent / Candida antarctica lipase B / toluene / 24 h / 45 °C

With Candida antarctica lipase B; sodium methylate; In methanol; toluene;

DOI:10.1021/jo010017f

upstream raw materials:

(3R,5S)-5-acetoxy-1-ethynyl-3-hydroxy-2-methylcyclohex-1-ene

4-nitro-benzoic acid

Downstream raw materials:

(3S,5S)-1-ethynyl-3,5-dihydroxy-2-methylcyclohex-1-ene