thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

Base Information

Chemical Name:thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester
CAS No.:263843-24-9
Molecular Formula:C₂₂H₂₄O₅S₄
Molecular Weight:496.694
Hs Code.:

Synonyms:thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

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Chemical Property of thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

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Technology Process of thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

There total 6 articles about thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 16629-19-9
thiophene-2-sulfonyl chloride

: 207737-17-5
toluene-4-thiosulfonic acid S-(2-tert-butyl-4-hydroxy-5-methylphenyl) ester

: 263843-24-9
thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1021/jm990281p

Reference yield:

: 62559-08-4
4-tert-butyl-2-nitrotoluene

: 263843-24-9
thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: H₂ / Raney Ni / methanol / 15 h / 35 °C / 2689.24 Torr

2: aq. NaNO₂; aq. 15percent H₂SO₄ / 0.5 h / 70 °C

3: Br₂; NaBr / methanol / 0.5 h / 5 - 40 °C

4: 79 percent / dithiothreitol; 0.02M KH₂PO₄ / ethanol / 4 h / Heating

5: 91 percent / pyridine / CCl₄

6: 73 percent / Et₃N / CH₂Cl₂

With pyridine; potassium dihydrogenphosphate; hydrogen; bromine; triethylamine; sodium bromide; sodium nitrite; diothiothreitol; nickel; In methanol; tetrachloromethane; ethanol; dichloromethane; 1: Reduction / 2: Diazotization / 3: Substitution / 4: Hydrolysis / 5: Tosylation / 6: Sulfonylation;
DOI:10.1021/jm990281p

Reference yield:

: 5781-02-2
5-(tert-butyl)-2-methylphenol

: 263843-24-9
thiophene-2-sulfonic acid 5-tert-butyl-2-methyl-4-(toluene-4-sulfonylsulfanyl)-phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: Br₂; NaBr / methanol / 0.5 h / 5 - 40 °C

2: 79 percent / dithiothreitol; 0.02M KH₂PO₄ / ethanol / 4 h / Heating

3: 91 percent / pyridine / CCl₄

4: 73 percent / Et₃N / CH₂Cl₂

With pyridine; potassium dihydrogenphosphate; bromine; triethylamine; sodium bromide; diothiothreitol; In methanol; tetrachloromethane; ethanol; dichloromethane; 1: Substitution / 2: Hydrolysis / 3: Tosylation / 4: Sulfonylation;
DOI:10.1021/jm990281p