3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

Base Information

Chemical Name:3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide
CAS No.:229342-78-3
Molecular Formula:C₂₀H₁₄Cl₄N₂O₃S
Molecular Weight:504.221
Hs Code.:

Synonyms:3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

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Chemical Property of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

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Technology Process of 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

There total 5 articles about 3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 229342-99-8
3-chloro-4-(chloromethyl)-2-thiophenecarbonyl chloride

: 945032-00-8
2-amino-5-chloro-N-(4-chlorophenyl)-3-methoxybenzamide

: 229342-78-3
3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/jm070125f

Reference yield:

: 4920-80-3
3-methoxy-2-nitrobenzoic acid

: 229342-78-3
3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 100 percent / oxalyl chloride; DMF / CH₂Cl₂ / 16 h / 20 °C

2: 48 percent / pyridine; 4-dimethylaminopyridine / 20 °C

3: aq. sodium hydrosulfite / tetrahydrofuran; dioxane

4: 61 percent / N-chlorosuccinimide / benzene / 50 - 55 °C

5: 67 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; dmap; sodium disulfite; N-chloro-succinimide; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm070125f

Reference yield:

: 15865-57-3
2-nitro-3-methoxybenzoyl chloride

: 229342-78-3
3-chloro-N-[4-chloro-2-[[(4-chlorophenyl)amino]carbonyl]-6-methoxyphenyl]-4-chloromethyl-2-thiophenecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / pyridine; 4-dimethylaminopyridine / 20 °C

2: aq. sodium hydrosulfite / tetrahydrofuran; dioxane

3: 61 percent / N-chlorosuccinimide / benzene / 50 - 55 °C

4: 67 percent / pyridine / CH₂Cl₂ / 0 - 20 °C

With pyridine; dmap; sodium disulfite; N-chloro-succinimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; benzene;
DOI:10.1021/jm070125f