3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

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Chemical Name:3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide
CAS No.:618428-60-7
Molecular Formula:C₃₆H₄₉N₅O₆S
Molecular Weight:679.881
Hs Code.:

3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Synonyms:3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

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Chemical Property of 3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

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Technology Process of 3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

There total 2 articles about 3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 3-{3(S)-[N-(N-ethyl-5-isoquinolinyloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide bromide

: 618428-60-7
3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Guidance literature:: With sodium hydrogencarbonate; sodium thiosulfate; In water; for 3h;
DOI:10.1002/ardp.200390003

Reference yield:

: 156880-90-9
(R)-N-tert-butyl-3-[(2S,3S)-2-hydroxy-3-[(S)-2-(5-isoquinolinyloxyacetyl)amino-3-methylbutanoyl]amino-4-phenylbutanoyl]-1,3-thiazolidine-4-carboxamide

: 618428-60-7
3-{3(S)-[N-(N-ethyl-1,2-dihydroisoquinolin-5-yloxyacetyl)-l-valinyl]amino-2(S)-hydroxy-4-phenylbutanoyl}-N-(tert-butyl)thiazolidine-4(R)-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / methanol / 3 h / 50 °C

2: 73 percent / NaHCO₃; Na₂S₂O₃ / H₂O / 3 h

With sodium hydrogencarbonate; sodium thiosulfate; In methanol; water;
DOI:10.1002/ardp.200390003