11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

Base Information

Chemical Name:11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one
CAS No.:153536-48-2
Molecular Formula:C₂₈H₃₁BrO₂
Molecular Weight:479.457
Hs Code.:

Synonyms:11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

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Chemical Property of 11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

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Technology Process of 11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

There total 5 articles about 11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 136721-62-5
17β-hydroxy-11β-<(4-hydroxymethyl)-phenyl>-17α-propynyl-estra-4,9-dien-3-one

: 153536-48-2
11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

Guidance literature:: With carbon tetrabromide; triphenylphosphine; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1016/0039-128X(94)90040-X

Reference yield:

: 10109-76-9
3,3-dimethoxy-estra-5⁽¹⁰⁾,9⁽¹¹⁾-diene-17-one

: 153536-48-2
11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 20 °C

2: Et₃N, hexafluoroacetone trihydrate, 85percent H₂O₂ / CH₂Cl₂ / 40 h / 0 °C

3: 92 percent / CuC₂l / tetrahydrofuran / 0.33 h / -10 °C

4: 92.7 percent / 2 N aq. HCl / methanol / 1 h / Ambient temperature

5: 90 percent / CBr₄, PPh₃ / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; carbon tetrabromide; dihydrogen peroxide; triethylamine; Hexafluoroacetone; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(94)90040-X

Reference yield:

: 17007-59-9
3,3-dimethoxy-17α-propynyl-estra-5(10),9(11)-dien-17β-ol

: 153536-48-2
11β-<4-(bromomethyl)phenyl>-17β-hydroxy-17α-propynyl-estra-4,9-dien-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N, hexafluoroacetone trihydrate, 85percent H₂O₂ / CH₂Cl₂ / 40 h / 0 °C

2: 92 percent / CuC₂l / tetrahydrofuran / 0.33 h / -10 °C

3: 92.7 percent / 2 N aq. HCl / methanol / 1 h / Ambient temperature

4: 90 percent / CBr₄, PPh₃ / CH₂Cl₂ / 1 h / Ambient temperature

With hydrogenchloride; carbon tetrabromide; dihydrogen peroxide; triethylamine; Hexafluoroacetone; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/0039-128X(94)90040-X