2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester

Base Information

• Chemical Name: 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester
• CAS No.: 146383-35-9
• Molecular Formula: C₂₆H₂₁NO₅S₂
• Molecular Weight: 491.588
• Mol file: 146383-35-9.mol

Synonyms:2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester

Chemical Property of 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester

There total 3 articles about 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(E)-2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-3-trifluoromethanesulfonyloxy-but-2-enoic acid benzhydryl ester → 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester (146383-35-9)

Guidance literature:

With triethylamine; In tetrahydrofuran; at -20 ℃;

DOI:10.1039/c39920001793

Reference yield:

(R)-2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-3-methyl-but-3-enoic acid benzhydryl ester → 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester (146383-35-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / O₃ / CH₂Cl₂; methanol / -78 °C

2: 87 percent / Et₃N / CH₂Cl₂ / -78 °C

3: 100 percent / Et₃N / tetrahydrofuran / -20 °C

With ozone; triethylamine; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/c39920001793

Reference yield:

2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-3-oxo-butyric acid benzhydryl ester → 2-((R)-2-Benzenesulfonylsulfanyl-4-oxo-azetidin-1-yl)-buta-2,3-dienoic acid benzhydryl ester (146383-35-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / Et₃N / CH₂Cl₂ / -78 °C

2: 100 percent / Et₃N / tetrahydrofuran / -20 °C

With triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1039/c39920001793

Downstream raw materials:

(R)-7-Oxo-3-trifluoromethanesulfonyloxy-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid benzhydryl ester

3,7-dioxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester

3-methylene-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid benzhydryl ester