CARBOMETHOXYIBOGAMINE HYDROCHLORIDE

Base Information

• Chemical Name: CARBOMETHOXYIBOGAMINE HYDROCHLORIDE
• CAS No.: 4503-12-2
• Molecular Formula: C21H26N2O2•ClH
• Molecular Weight: 374.95
• Mol file: 4503-12-2.mol

Synonyms:6,9-METHANO-8H-PYRIDO(1′,2′:1,2)AZEPINO(4,5-b)INDOLE-6(6aH)-CARBOXYLIC ACID, 7,8,9,10,12,13- HEXAHYDRO-6-ETHYL-13a-HYDROXY-, METHYL ESTER, HYDROCHLORIDE;(?)-CORONARIDINE MONOHYDROCHLORIDE;IBOGAMINE-18-CARBOXYLIC ACID, METHYL ESTER, HYDROCHLORIDE;

Chemical Property of CARBOMETHOXYIBOGAMINE HYDROCHLORIDE

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CARBOMETHOXYIBOGAMINE HYDROCHLORIDE

There total 5 articles about CARBOMETHOXYIBOGAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

catharinthine (2468-21-5) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogen; platinum(IV) oxide / methanol / 0.08 h / 760.05 Torr / Inert atmosphere

2: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

3: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

4: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; platinum(IV) oxide; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

Reference yield:

methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate (136118-90-6) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 0.42 h / Inert atmosphere

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

Reference yield:

(+)-dihydrocatharanthine (38542-83-5) → (+)-coronaridine hydrochloride (28888-46-2,4503-12-2,7237-52-7)

Guidance literature:

Multi-step reaction with 3 steps

1: [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺ / methanol / 50 °C / Inert atmosphere; Flow reactor; UV-irradiation

2: trifluoroacetic acid / toluene / 3 h / 120 °C / Inert atmosphere

3: hydrogenchloride / diethyl ether / Inert atmosphere

With hydrogenchloride; [Ir(C₆H₂F₂-C₅H₃NCF₃)₂(4,4′-di-tert-butyl-2,2′-dipyridyl)]⁺; trifluoroacetic acid; In methanol; diethyl ether; toluene;

DOI:10.1021/ja506170g

upstream raw materials:

(+)-dihydrocatharanthine

catharinthine

(+)-coronaridine

methyl 4-cyano-5-ethyl-1,4,7,8,9,10-hexahydro-2H-3,7-methanoazacycloundecino<5,4-b>indole-9-carboxylate

Refernces