(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Base Information

Chemical Name:(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester
CAS No.:1026864-32-3
Molecular Formula:C₅₁H₅₆N₄O₈
Molecular Weight:853.028
Hs Code.:

(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Synonyms:(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

There total 11 articles about (E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 15100-75-1,75898-47-4
L-phenylalanine tert-butyl ester hydrochloride

: 1026864-32-3
(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AlMe₃

2: H₂ / Pd/C

3: 4-methylmorpholine

4: TFA / tetrahydrofuran / 23 °C

5: HOBT, NMM, EDC / tetrahydrofuran / 23 °C

With 4-methyl-morpholine; hydrogen; trimethylaluminum; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm9800696

Reference yield:

: 157717-58-3
(S)-3-azido-4,4-dimethyldihydrofuran-2(3H)-one

: 1026864-32-3
(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: AlMe₃

2: H₂ / Pd/C

3: 4-methylmorpholine

4: TFA / tetrahydrofuran / 23 °C

5: HOBT, NMM, EDC / tetrahydrofuran / 23 °C

With 4-methyl-morpholine; hydrogen; trimethylaluminum; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm9800696

Reference yield:

: 1026967-98-5
(S)-2-((S)-2-Azido-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionic acid tert-butyl ester

: 1026864-32-3
(E)-(S)-4-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-hydroxy-3,3-dimethyl-butyrylamino)-3-phenyl-propionylamino]-6-(trityl-carbamoyl)-hex-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C

2: 4-methylmorpholine

3: TFA / tetrahydrofuran / 23 °C

4: HOBT, NMM, EDC / tetrahydrofuran / 23 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1021/jm9800696