(+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine

Base Information

• Chemical Name: (+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine
• CAS No.: 177796-08-6
• Molecular Formula: C₂₅H₄₃NO₂SSi
• Molecular Weight: 449.773
• Mol file: 177796-08-6.mol

Synonyms:(+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine

Chemical Property of (+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine

There total 3 articles about (+)-(S_S,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2S,4R)-4-Isopropyl-2-p-tolyl-4H,5H-2λ4-[1,2,3]oxathiazole 2-oxide (170900-87-5) → (+)-(SS,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine (177796-08-6)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran; diethyl ether / -78 °C

2: EtMe₂N, DMAP / CH₂Cl₂ / 18 h

3: 1.) n-BuLi, 3.) trimethylsilyl triflate, 4.) n-BuLi

With dmap; n-butyllithium; N,N-dimethyl-ethanamine; trimethylsilyl trifluoromethanesulfonate; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja9530735

Reference yield:

C13H21NO2S → (+)-(SS,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine (177796-08-6)

Guidance literature:

Multi-step reaction with 2 steps

1: EtMe₂N, DMAP / CH₂Cl₂ / 18 h

2: 1.) n-BuLi, 3.) trimethylsilyl triflate, 4.) n-BuLi

With dmap; n-butyllithium; N,N-dimethyl-ethanamine; trimethylsilyl trifluoromethanesulfonate; In dichloromethane;

DOI:10.1021/ja9530735

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) + (+)-(SS)-N(1R)-N-[1-((tert-butyldimethylsilyl)oxy)-methyl-2-methylpropyl]-S-methyl-S-(4-methylphenyl)sulfoximide (177796-04-2) → (+)-(SS,N(1R))-N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-(cyclohex-1-en-1-ylmethyl)-S-(4-methylphenyl)sulfoximine (177796-08-6)

Guidance literature:

With n-butyllithium; trimethylsilyl trifluoromethanesulfonate; Yield given. Multistep reaction;

DOI:10.1021/ja9530735

upstream raw materials:

cyclohexanone

(+)-(S_S)-N(1R)-N-[1-((tert-butyldimethylsilyl)oxy)-methyl-2-methylpropyl]-S-methyl-S-(4-methylphenyl)sulfoximide

(2S,4R)-4-Isopropyl-2-p-tolyl-4H,5H-2λ⁴-[1,2,3]oxathiazole 2-oxide

Downstream raw materials:

(-)-(S_S,N(1R),1R,1'R,2S,2'Z)-1-(2'-{[N-(1-{[(tert-butyldimethylsilyl)oxy]methyl}-2-methylpropyl)-S-4-(methylphenyl)sulfonimidoyl]methylene}cyclohex-1'-yl)-2-[(tert-butyldimethylsilyl)oxy]propan-1-ol

C₃₇H₆₇NO₄SSi₂