(S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Base Information

• Chemical Name: (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole
• CAS No.: 1373357-05-1
• Molecular Formula: C₃₅H₅₀N₂O₂
• Molecular Weight: 530.794
• Mol file: 1373357-05-1.mol

Synonyms:(S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Chemical Property of (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

Chemical Property:

Purity/Quality:

99%+ ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole

There total 2 articles about (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

(S)-valinol (2026-48-4,473-75-6) + 2,2-di(4-tert-butylphenylmethyl)malononitrile (1373356-95-6) → (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole (1373357-05-1,2757082-36-1)

Guidance literature:

With zinc(II) chloride; In 1,2-dichloro-benzene; at 150 ℃; for 12h; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.02.021

Reference yield:

1-(tert-butyl)-4-(iodomethyl)benzene (140874-33-5) → (S)-2-(1,3-bis(4-tert-butylphenyl)-2-((S)-4,5-dihydro-4-isopropyloxazol-2-yl)propan-2-yl)-4,5-dihydro-4-isopropyloxazole (1373357-05-1,2757082-36-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

2: zinc(II) chloride / 1,2-dichloro-benzene / 12 h / 150 °C / Inert atmosphere

With 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc(II) chloride; In N,N-dimethyl-formamide; 1,2-dichloro-benzene;

DOI:10.1016/j.tetasy.2012.02.021

upstream raw materials:

(S)-valinol

2,2-di(4-tert-butylphenylmethyl)malononitrile

1-(tert-butyl)-4-(iodomethyl)benzene