(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

Base Information

Chemical Name:(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital
CAS No.:147118-48-7
Molecular Formula:C₂₄H₃₃N₃O₈
Molecular Weight:491.541
Hs Code.:

Synonyms:(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

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Chemical Property of (S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

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Technology Process of (S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

There total 8 articles about (S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 147200-16-6
(R)-2-Benzyloxy-3-butoxy-propan-1-ol

: 147118-48-7
(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

Guidance literature:: Multi-step reaction with 5 steps

1: 92 percent / pyridine / 12 h / Ambient temperature

2: 98 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

3: 96 percent / NaI / acetone / 12 h / 60 °C

4: 870 mg / CF₃COOH / benzene / 12 h / Ambient temperature

5: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 55 deg C, 12 h

With pyridine; hydrogen; sodium hydride; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.2605

Reference yield:

: 147118-43-2
2-((S)-2-Benzyloxy-3-butoxy-propoxy)-tetrahydro-pyran

: 147118-48-7
(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

Guidance literature:: Multi-step reaction with 6 steps

1: pyridinium p-toluenesulfonate (PPTS) / ethanol / 3 h / 55 °C

2: 92 percent / pyridine / 12 h / Ambient temperature

3: 98 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

4: 96 percent / NaI / acetone / 12 h / 60 °C

5: 870 mg / CF₃COOH / benzene / 12 h / Ambient temperature

6: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 55 deg C, 12 h

With pyridine; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.2605

Reference yield:

: 147118-44-3
(S)-2-O-benzyl-1-O-butyl-3-O-tosylglycerol

: 147118-48-7
(S)-3-<2-(R)-<(aminocarbonyl)oxy>-3-butoxypropyl>-5-ethyl-5-phenyl-1-propionyloxymethylbarbital

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / H₂ / 5percent Pd/C / ethanol / Ambient temperature

2: 96 percent / NaI / acetone / 12 h / 60 °C

3: 870 mg / CF₃COOH / benzene / 12 h / Ambient temperature

4: 1.) NaH / 1.) DMF, 0 deg C, 1 h, 2.) DMF, 55 deg C, 12 h

With hydrogen; sodium hydride; trifluoroacetic acid; sodium iodide; palladium on activated charcoal; In ethanol; acetone; benzene;
DOI:10.1248/cpb.40.2605