N--L-leucine, methyl ester

Base Information

Chemical Name:N--L-leucine, methyl ester
CAS No.:120915-52-8
Molecular Formula:C₂₂H₃₂N₂O₄
Molecular Weight:388.507
Hs Code.:

N-<N-(cyclopentylcarbonyl)-L-phenylalanyl>-L-leucine, methyl ester

Synonyms:N--L-leucine, methyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N--L-leucine, methyl ester

Chemical Property:

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Technology Process of N--L-leucine, methyl ester

There total 4 articles about N--L-leucine, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.6%

: 3400-45-1
cyclopentanecarboxylic acid

: 38155-45-2
methyl L-phenylalanyl-L-leucinate hydrochloride

: 120915-52-8
N--L-leucine, methyl ester

Guidance literature:: With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 16h;
DOI:10.1021/jm00069a001

Reference yield:

: 2666-93-5
(S)-Leu-OMe

: 120915-52-8
N--L-leucine, methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66.1 percent / DCC, HOBT, iPr₂NEt / tetrahydrofuran / 14 h / 0 - 20 °C

2: 98 percent / HCl in acetic acid / 1 h

3: 57.6 percent / iPr₂NEt, HOBt, DCC / dimethylformamide / 16 h / 0 °C

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00069a001

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 120915-52-8
N--L-leucine, methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 66.1 percent / DCC, HOBT, iPr₂NEt / tetrahydrofuran / 14 h / 0 - 20 °C

2: 98 percent / HCl in acetic acid / 1 h

3: 57.6 percent / iPr₂NEt, HOBt, DCC / dimethylformamide / 16 h / 0 °C

With hydrogenchloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm00069a001