Technology Process of (4S,5R)-2,2-dimethyl-4-(2-methylpropan-1-yl)-5-<(1S)-1--2-cyclohexylethyl>-1,3-dioxolane
There total 24 articles about (4S,5R)-2,2-dimethyl-4-(2-methylpropan-1-yl)-5-<(1S)-1--2-cyclohexylethyl>-1,3-dioxolane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, reflux, 1 h
2: diethyl ether / 0 - 5 °C
3: 54 percent / LiAlH4 / tetrahydrofuran / 2.5 h / 0 - 5 °C
4: 90 percent / H2 / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature
6: 1.) t-BuLi / 1.) pentane, diethyl ether, -80 to -90 deg C, 5 min, 2.) ether, r.t., 1 h
7: 64 percent / H2 / Raney nickel / methanol / 24 h / 3040 Torr / Ambient temperature
8: CH2Cl2 / 18 h / Ambient temperature
With
lithium aluminium tetrahydride; n-butyllithium; hydrogen; tert.-butyl lithium;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00064a013
- Guidance literature:
-
Multi-step reaction with 7 steps
1: diethyl ether / 0 - 5 °C
2: 54 percent / LiAlH4 / tetrahydrofuran / 2.5 h / 0 - 5 °C
3: 90 percent / H2 / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature
5: 1.) t-BuLi / 1.) pentane, diethyl ether, -80 to -90 deg C, 5 min, 2.) ether, r.t., 1 h
6: 64 percent / H2 / Raney nickel / methanol / 24 h / 3040 Torr / Ambient temperature
7: CH2Cl2 / 18 h / Ambient temperature
With
lithium aluminium tetrahydride; hydrogen; tert.-butyl lithium;
palladium on activated charcoal; nickel;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane;
DOI:10.1021/jo00064a013
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) n-butyllithium / 1.) THF, hexane, -40 deg C, 1.5 h, 2.) THF, r.t, 20 h
2: 90 percent / H2 / 10 percent Pd/C / methanol / 24 h / 760 Torr / Ambient temperature
4: 1.) t-BuLi / 1.) pentane, diethyl ether, -80 to -90 deg C, 5 min, 2.) ether, r.t., 1 h
5: 64 percent / H2 / Raney nickel / methanol / 24 h / 3040 Torr / Ambient temperature
6: CH2Cl2 / 18 h / Ambient temperature
With
n-butyllithium; hydrogen; tert.-butyl lithium;
palladium on activated charcoal; nickel;
In
methanol; dichloromethane;
DOI:10.1021/jo00064a013
