methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate

Base Information

• Chemical Name: methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate
• CAS No.: 1101271-57-1
• Molecular Formula: C₂₁H₁₈Cl₂O₈
• Molecular Weight: 469.275

Synonyms:methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate

Chemical Property of methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate

Chemical Property:

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Technology Process of methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate

There total 1 articles about methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-oxoacetate (1101271-60-6) + 4-Hydroxy-3-(4-methoxyphenyl)-furan-2(5H)-one (93831-11-9) → methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate (1101271-57-1)

Guidance literature:

4-Hydroxy-3-(4-methoxyphenyl)-furan-2(5H)-one; With lithium diisopropyl amide; In tetrahydrofuran; at -30 ℃; for 0.5h; Inert atmosphere;

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-oxoacetate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; Inert atmosphere;

DOI:10.1021/jo802038z

Reference yield: 95.0%

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate (1101271-57-1) → (E)-methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)acetate (872451-20-2)

Guidance literature:

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate; With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

In toluene; for 8h; Inert atmosphere; UV-irradiation;

DOI:10.1021/jo802038z

Reference yield:

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-hydroxy-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-2-yl)acetate (1101271-57-1) → methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)acetate

Guidance literature:

With pyridine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo802038z

upstream raw materials:

methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-oxoacetate

4-Hydroxy-3-(4-methoxyphenyl)-furan-2(5H)-one

Downstream raw materials:

(E)-methyl 2-(3,5-dichloro-4-methoxyphenyl)-2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)acetate

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