methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

Base Information

Chemical Name:methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate
CAS No.:872674-79-8
Molecular Formula:C₃₃H₃₀ClNO₃
Molecular Weight:524.059
Hs Code.:

Synonyms:methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

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Chemical Property of methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

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Technology Process of methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

There total 5 articles about methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-[(4-chloro-phenyl)-hydrazono]-pentanoic acid ethyl ester

: 872674-79-8
methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ZnCl₂ / 140 °C

2.1: NaH / dimethylformamide / 0.5 h / 0 °C

2.2: 17 percent / dimethylformamide / 0 - 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 10 °C

4.1: PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; zinc(II) chloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Fisher indole synthesis / 4.1: Mitsunobu reaction;
DOI:10.1021/jm0507882

Reference yield:

: 872674-73-2
ethyl [5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]acetate

: 872674-79-8
methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 0.5 h / 10 °C

2: PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; dichloromethane; 2: Mitsunobu reaction;
DOI:10.1021/jm0507882

Reference yield:

: 3446-72-8
5-chloro-2-methyl-1H-indole-3-acetic acid ethyl ester

: 872674-79-8
methyl [4-[2-[5-chloro-1-(diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]phenyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 17 percent / dimethylformamide / 0 - 20 °C

2.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 10 °C

3.1: PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3.1: Mitsunobu reaction;
DOI:10.1021/jm0507882