N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

Base Information

Chemical Name:N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester
CAS No.:510713-99-2
Molecular Formula:C₃₀H₄₆F₂N₂O₈Si
Molecular Weight:628.786
Hs Code.:

Synonyms:N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

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Chemical Property of N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

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Technology Process of N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

There total 11 articles about N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 510713-99-2
N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / DMAP; EDC / CH₂Cl₂ / 36 h / 20 °C

2.1: H₂ / 10 percent Pd/C / methanol; propan-2-ol / 1.5 h / 2068.59 Torr

3.1: aq. NaOH / tetrahydrofuran / 1 h / 0 °C

3.2: 402 mg / HOBt; DCC / dimethylformamide; CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium hydroxide; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1055/s-2002-35616

Reference yield:

: 34897-61-5
N-(benzyloxycarbonyl)-L-glutamic acid α-t-butyl ester dicyclohexylamine salt

: 510713-99-2
N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: 86 percent / DMAP; EDC / CH₂Cl₂ / 36 h / 20 °C

2.1: H₂ / 10 percent Pd/C / methanol; propan-2-ol / 1.5 h / 2068.59 Torr

3.1: aq. NaOH / tetrahydrofuran / 1 h / 0 °C

3.2: 402 mg / HOBt; DCC / dimethylformamide; CH₂Cl₂ / 48 h / 20 °C

With dmap; sodium hydroxide; hydrogen; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol;
DOI:10.1055/s-2002-35616

Reference yield:

: 357958-50-0
N-Cbz-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

: 510713-99-2
N-Cbz-difluorooxazolidine-γ-L-glutamic acid α-tert-butyl ester γ-(2-trimethylsilyl)ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: H₂ / 10 percent Pd/C / methanol; propan-2-ol / 1.5 h / 2068.59 Torr

2.1: aq. NaOH / tetrahydrofuran / 1 h / 0 °C

2.2: 402 mg / HOBt; DCC / dimethylformamide; CH₂Cl₂ / 48 h / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; isopropyl alcohol;
DOI:10.1055/s-2002-35616