3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

Base Information

• Chemical Name: 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide
• CAS No.: 138571-15-0
• Molecular Formula: C₃₆H₆₀N₄O₄
• Molecular Weight: 612.897
• Mol file: 138571-15-0.mol

Synonyms:3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

Chemical Property of 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

There total 15 articles about 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide (138571-14-9) → 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide (138571-15-0)

Guidance literature:

With ethandithiol; triethylamine; In methanol; for 48h; Ambient temperature;

DOI:10.1021/jm00083a006

Reference yield:

3-phenylglutaric acid anhydride (4160-80-9) → 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide (138571-15-0)

Guidance literature:

Multi-step reaction with 14 steps

1: 86 percent / NaBH₄ / tetrahydrofuran / a) 0 deg C, 1 h, b) RT, 0.5 h

2: 100 percent / 2.5 M aq. NaOH

3: 57 percent / hexamethylphosphoric acid triamide; ethanol / Ambient temperature

4: 1.) oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, DMSO, -78 deg C, 0.5 h, 2.) CH₂Cl₂, DMSO, from -78 deg C to RT

5: TsOH / benzene / 2 h / 120 °C

6: 93 percent / 1 M aq. NaOH / tetrahydrofuran / 10 h / Heating

7: 1.) pivaloyl chloride, Et₃N / 1.) THF, -78 deg C, 2.) from -78 deg C to 0 deg C, 40 min

8: 1.) potassium hexamethyldisilazide, 2.) 2,4,6-triisopropylbenzenesulfonyl azide, acetic acid / 1.) toluene, THF, -78 deg C, 0.5 h, 2.) toluene, THF, from -78 deg C to 35 deg C, 0.5 h

9: 67 percent / acetic acid / tetrahydrofuran; H₂O / 6 h / Heating

10: 1.) 3A molecular sieves, 2.) NaCNBH₄ / 1.) MeOH, 0.5 h, 2.) MeOH, THF, RT, 3 h

11: 84 percent / dimethylformamide / 5 h / 110 °C

12: 32 mg / sat. HCl/EtOAc / Ambient temperature

13: N-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

14: 57 percent / triethylamine, ethanedithiol / methanol / 48 h / Ambient temperature

With hydrogenchloride; ethandithiol; sodium hydroxide; sodium tetrahydroborate; oxalyl dichloride; 3 A molecular sieve; 2,4,6-Triisopropylbenzenesulfonyl azide; pivaloyl chloride; potassium hexamethylsilazane; sodium cyanoborohydride; benzotriazol-1-ol; toluene-4-sulfonic acid; acetic acid; ethyl acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00083a006

Reference yield:

4-phenyltetrahydropyran-2-one (61198-49-0,61949-75-5,71302-21-1,25547-53-9) → 3(S)-amino-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide (138571-15-0)

Guidance literature:

Multi-step reaction with 13 steps

1: 100 percent / 2.5 M aq. NaOH

2: 57 percent / hexamethylphosphoric acid triamide; ethanol / Ambient temperature

3: 1.) oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, DMSO, -78 deg C, 0.5 h, 2.) CH₂Cl₂, DMSO, from -78 deg C to RT

4: TsOH / benzene / 2 h / 120 °C

5: 93 percent / 1 M aq. NaOH / tetrahydrofuran / 10 h / Heating

6: 1.) pivaloyl chloride, Et₃N / 1.) THF, -78 deg C, 2.) from -78 deg C to 0 deg C, 40 min

7: 1.) potassium hexamethyldisilazide, 2.) 2,4,6-triisopropylbenzenesulfonyl azide, acetic acid / 1.) toluene, THF, -78 deg C, 0.5 h, 2.) toluene, THF, from -78 deg C to 35 deg C, 0.5 h

8: 67 percent / acetic acid / tetrahydrofuran; H₂O / 6 h / Heating

9: 1.) 3A molecular sieves, 2.) NaCNBH₄ / 1.) MeOH, 0.5 h, 2.) MeOH, THF, RT, 3 h

10: 84 percent / dimethylformamide / 5 h / 110 °C

11: 32 mg / sat. HCl/EtOAc / Ambient temperature

12: N-hydroxybenzotriazole, 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Ambient temperature

13: 57 percent / triethylamine, ethanedithiol / methanol / 48 h / Ambient temperature

With hydrogenchloride; ethandithiol; sodium hydroxide; oxalyl dichloride; 3 A molecular sieve; 2,4,6-Triisopropylbenzenesulfonyl azide; pivaloyl chloride; potassium hexamethylsilazane; sodium cyanoborohydride; benzotriazol-1-ol; toluene-4-sulfonic acid; acetic acid; ethyl acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

DOI:10.1021/jm00083a006

upstream raw materials:

3(S)-azido-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

4-phenyltetrahydropyran-2-one

3-phenylglutaric acid anhydride

3-phenylglutaric acid

Downstream raw materials:

3(S)-(acetylamino)-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide

3(S)-<(tert-butyloxycarbonyl)amino>-α(S)-butyl-N-<4(S)-<(butylamino)carbonyl>-1(S)-(cyclohexylmethyl)-2(S)-hydroxy-5-methylhexyl>-2-oxo-4(R)-phenyl-1-piperidineacetamide