methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate

Base Information

• Chemical Name: methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate
• CAS No.: 861966-97-4
• Molecular Formula: C₃₁H₄₃N₃O₃
• Molecular Weight: 505.701
• Mol file: 861966-97-4.mol

Synonyms:methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate

Chemical Property of methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate

There total 2 articles about methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

methyl 2-bromo-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate (861967-00-2) + 2-(cyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (141091-37-4) → methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate (861966-97-4)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; at 80 ℃; for 0.333333h;

DOI:10.1021/jm050056+

Reference yield:

[2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]acetic acid (735287-38-4) → methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate (861966-97-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / DIEA; HATU / CH₂Cl₂ / 12 h

2: 68 percent / Na₂CO₃; Pd(PPh₃)2Cl₂ / 0.33 h / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; 2: Suzuki coupling;

DOI:10.1021/jm050056+

Reference yield:

methyl 2-cyclohex-1-en-1-yl-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate (861966-97-4) → methyl 2,3-dicyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate (861967-37-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 12h;

DOI:10.1021/jm050056+

upstream raw materials:

methyl 2-bromo-3-cyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate

2-(cyclohex-1-en-1-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

[2-bromo-3-cyclohexyl-6-(methoxycarbonyl)-1H-indol-1-yl]acetic acid

Downstream raw materials:

methyl 2,3-dicyclohexyl-1-{2-[4-(dimethylamino)piperidin-1-yl]-2-oxoethyl}-1H-indole-6-carboxylate