4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

Base Information

Chemical Name:4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide
CAS No.:1266477-86-4
Molecular Formula:C₁₆H₁₅ClN₆O₂S
Molecular Weight:390.853
Hs Code.:

Synonyms:4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

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Chemical Property of 4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

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Technology Process of 4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

There total 5 articles about 4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.1%

: N-(tert-butyl)-4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

: 1266477-86-4
4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

Guidance literature:: With boron trichloride; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acsmedchemlett.7b00239

Reference yield:

: 98-58-8
4-bromobenzenesulfonyl chloride

: 1266477-86-4
4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C

2: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

3: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

4: boron trichloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; boron trichloride; sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; dichloromethane; water; 3: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.7b00239

Reference yield:

: 93281-65-3
4-bromo-(N-tert-butyl)benzenesulfonamide

: 1266477-86-4
4-(5-chloro-4-((5-cyclopropyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

2: sodium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 2 h / 95 °C / Inert atmosphere

3: boron trichloride / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; boron trichloride; sodium carbonate; In 1,4-dioxane; dichloromethane; water; 2: |Suzuki Coupling;
DOI:10.1021/acsmedchemlett.7b00239