1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

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Chemical Name:1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one
CAS No.:1454864-20-0
Molecular Formula:C₃₈H₄₇N₅O₆Si
Molecular Weight:697.907
Hs Code.:

Synonyms:1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

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Chemical Property of 1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

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Technology Process of 1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

There total 4 articles about 1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1454864-18-6
2′-deoxy-5′-O-(4,4′-dimethoxytrityl)-3′-O-thexyldimethylsilyluridine

: 1454864-20-0
1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

Guidance literature:: 2′-deoxy-5′-O-(4,4′-dimethoxytrityl)-3′-O-thexyldimethylsilyluridine; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere;

With 2,4,6-triisopropylphenylsulfonyl chloride; In tetrahydrofuran; for 0.5h; Inert atmosphere;

With sodium azide; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1039/c3pp25402j

Reference yield:

: 951-78-0,63844-76-8
2'-deoxyuridine

: 1454864-20-0
1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine

2.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: 0.5 h / Inert atmosphere

3.3: 20 °C / Inert atmosphere

With pyridine; 1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c3pp25402j

Reference yield:

: 23669-79-6
DMT-dU

: 1454864-20-0
1-[2-deoxy-5-O-(4,4′-dimethoxytrityl)-3-O-thexyldimethylsilyl-β-D-ribofuranosyl]tetrazolo[4,5-c]pyrimidin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 24 h / 20 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: 0.5 h / Inert atmosphere

2.3: 20 °C / Inert atmosphere

With 1H-imidazole; 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c3pp25402j