(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Base Information

Chemical Name:(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide
CAS No.:141045-58-1
Molecular Formula:C₁₉H₂₀N₂O₄S
Molecular Weight:372.445
Hs Code.:

Synonyms:(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Suppliers and Price of (R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

There total 6 articles about (R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 133678-83-8
(R)-(+)-2-methyl-2-(4-methylphenyl)-3-oxo-4-butanolide

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 141045-58-1
(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Guidance literature:: In ethanol; for 2.5h; Heating;
DOI:10.1021/jo00038a041

Reference yield:

: 79443-97-3
methyl 2-(4-methylphenyl)propanoate

: 141045-58-1
(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Guidance literature:: Multi-step reaction with 6 steps

1: 1) i-Pr₂NH, n-BuLi / 1) THF, -78 deg C, 1 h, 2) 0 deg C, 30 min

2: 95 percent / 2N NaOH / H₂O / 1 h / 25 °C / pig liver esterase, pH 7.2

3: 95 percent / oxalyl chloride / benzene / 12 h / 45 °C

4: 80 percent / diethyl ether / 0.25 h / 0 °C

5: 6 N HCl / tetrahydrofuran / 12 h / 20 °C

6: 90 percent / ethanol / 2.5 h / Heating

With hydrogenchloride; sodium hydroxide; n-butyllithium; oxalyl dichloride; diisopropylamine; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1021/jo00038a041

Reference yield:

: 127047-04-5
dimethyl 2-methyl-2-(4-methylphenyl)malonate

: 141045-58-1
(R)-(+)-2-methyl-2-(4-methylphenyl)-3-<<(4-methylphenyl)sulfonyl>hydrazono>-4-butanolide

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 2N NaOH / H₂O / 1 h / 25 °C / pig liver esterase, pH 7.2

2: 95 percent / oxalyl chloride / benzene / 12 h / 45 °C

3: 80 percent / diethyl ether / 0.25 h / 0 °C

4: 6 N HCl / tetrahydrofuran / 12 h / 20 °C

5: 90 percent / ethanol / 2.5 h / Heating

With hydrogenchloride; sodium hydroxide; oxalyl dichloride; In tetrahydrofuran; diethyl ether; ethanol; water; benzene;
DOI:10.1021/jo00038a041