C₂₉H₂₅N₉O

Base Information

• Chemical Name: C₂₉H₂₅N₉O
• CAS No.: 1421271-38-6
• Molecular Formula: C₂₉H₂₅N₉O
• Molecular Weight: 515.577
• Mol file: 1421271-38-6.mol

Synonyms:C₂₉H₂₅N₉O

Chemical Property of C₂₉H₂₅N₉O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₉H₂₅N₉O

There total 15 articles about C₂₉H₂₅N₉O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,4-triazole-3-carboxylic acid (4928-87-4) + 5-((1R,3s,5S)-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3-yl)-8-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidine (1421271-46-6) → C29H25N9O (1421271-38-6)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

5,7-dihydroxypyrazolo[1,5-a]pyrimidine (57489-70-0) → C29H25N9O (1421271-38-6)

Guidance literature:

Multi-step reaction with 11 steps

1: trichlorophosphate; N,N-dimethyl-aniline / 16 h / 0 - 60 °C

2: ammonium hydroxide / 2.5 h / 85 °C / Sealed tube

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 45 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 16 h / 100 °C

5: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 45 °C

6: N-iodo-succinimide / dichloromethane; acetonitrile / 1.5 h / 20 °C

7: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; 1,4-dioxane / 15 h / 100 °C

8: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

9: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; acetonitrile / 1 h / 125 °C / Inert atmosphere; Sealed tube; Microwave irradiation

10: trifluoroacetic acid / water / 48 h

11: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With ammonium hydroxide; N-Bromosuccinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; benzotriazol-1-ol; N,N-dimethyl-aniline; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trichlorophosphate; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(1R,5S)-tert-butyl 3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1 ]oct-2-ene-8-carboxylate (1245646-51-8) → C29H25N9O (1421271-38-6)

Guidance literature:

Multi-step reaction with 9 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; 1,1'-bis-(diphenylphosphino)ferrocene; potassium acetate / 1,4-dioxane / 16 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 16 h / 100 °C

3: palladium 10% on activated carbon; hydrogen / ethyl acetate / 16 h / 45 °C

4: N-iodo-succinimide / dichloromethane; acetonitrile / 1.5 h / 20 °C

5: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / water; 1,4-dioxane / 15 h / 100 °C

6: N-Bromosuccinimide / dichloromethane; acetonitrile / 0.5 h / 20 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; acetonitrile / 1 h / 125 °C / Inert atmosphere; Sealed tube; Microwave irradiation

8: trifluoroacetic acid / water / 48 h

9: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 2 h / 20 °C

With 1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; hydrogen; potassium acetate; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

(1R,5S)-tert-butyl 3-(((trifluoromethyl)sulfonyl)oxy)-8-azabicyclo[3.2.1 ]oct-2-ene-8-carboxylate

N-Boc-nortropinone

5,7-dihydroxypyrazolo[1,5-a]pyrimidine

tert-butyl 3-(7-(bis((2-(trimethylsilyl)ethoxy)methyl)amino)pyrazolo[1,5-a]pyrimidin-5-yl)-8-azabicyclo[3.2.1]oct-2-ene-8-carboxylate