(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

Base Information

Chemical Name:(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide
CAS No.:130675-49-9
Molecular Formula:C₂₁H₂₄N₂O₅
Molecular Weight:384.432
Hs Code.:

Synonyms:(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

Suppliers and Price of (2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

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Technology Process of (2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

There total 7 articles about (2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 130675-48-8,130793-19-0,130793-20-3
(S)-4-Methoxymethoxymethyl-3-((3S,4R)-2-oxo-1,4-diphenyl-azetidin-3-yl)-oxazolidin-2-one

: 130675-49-9
(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; at 80 ℃; for 48h;
DOI:10.1248/cpb.38.1601

Reference yield:

: 538-51-2
benzylidene phenylamine

: 130675-49-9
(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

2: 46.5 percent / H₂ / 10percent Pd-C / ethanol / 48 h / 80 °C

With TEA; hydrogen; trifluoroacetic anhydride; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1248/cpb.38.1601

Reference yield:

: 130675-45-5
(4S)-4-<(methoxymethoxy)methyl>-2-oxazolidinone

: 130675-49-9
(2S)-2-<(4S)-4-<(methoxymethoxy)methyl>oxazolidin-2-on-3-yl>-3-phenylpropionanilide

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / NaH / tetrahydrofuran; dimethylformamide / 20 h / Ambient temperature

2: 86 percent / H₂ / 5percent Pd-C / ethanol / 6 h / 760 Torr / Ambient temperature

3: 67 percent / TEA, trifluoroacetic anhydride / CH₂Cl₂ / 20 h / 0 °C

4: 46.5 percent / H₂ / 10percent Pd-C / ethanol / 48 h / 80 °C

With TEA; hydrogen; sodium hydride; trifluoroacetic anhydride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.1601