2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

Base Information

Chemical Name:2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine
CAS No.:79722-49-9
Molecular Formula:C₁₇H₁₇N₅O₄
Molecular Weight:355.353
Hs Code.:

Synonyms:2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

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Chemical Property of 2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

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Technology Process of 2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

There total 4 articles about 2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 79722-48-8
2-amino-6-carbethoxy-5-(chloromethyl)-3-cyanopyrazine

: 619-45-4
4-methoxycarbonyl aniline

: 79722-49-9
2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

Guidance literature:: With potassium carbonate; In acetonitrile; for 16h; Ambient temperature;
DOI:10.1021/jo00340a025

Reference yield:

: 638-07-3
ethyl (2-chloroaceto)acetate

: 79722-49-9
2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 53 percent / nitrosyl chloride / tetrahydrofuran / 16 h

2: 53 percent / conc. HCl / propan-2-ol / 16 h / Ambient temperature

3: 77 percent / trimethyl phosphite / propan-1-ol / 0 °C / overnight

4: 76 percent / potassium carbonate / acetonitrile / 16 h / Ambient temperature

With hydrogenchloride; potassium carbonate; nitrosylchloride; phosphorous acid trimethyl ester; In tetrahydrofuran; propan-1-ol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo00340a025

Reference yield:

: 50382-11-1
ethyl γ-chloro-α-oximinoacetoacetate

: 79722-49-9
2-amino-6-carbethoxy-3-cyano-5-<<4-(carbomethoxy)anilino>methyl>pyrazine

Guidance literature:: Multi-step reaction with 3 steps

1: 53 percent / conc. HCl / propan-2-ol / 16 h / Ambient temperature

2: 77 percent / trimethyl phosphite / propan-1-ol / 0 °C / overnight

3: 76 percent / potassium carbonate / acetonitrile / 16 h / Ambient temperature

With hydrogenchloride; potassium carbonate; phosphorous acid trimethyl ester; In propan-1-ol; isopropyl alcohol; acetonitrile;
DOI:10.1021/jo00340a025