(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

Base Information

Chemical Name:(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione
CAS No.:100665-27-8
Molecular Formula:C₁₉H₂₁N₃O₄S
Molecular Weight:387.459
Hs Code.:

Synonyms:(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

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Chemical Property of (5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

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Technology Process of (5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

There total 3 articles about (5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62305-89-9
(R)-5-oxothiomorpholine-3-carboxylic acid

: 100665-27-8
(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 1-hydroxybenzotriazole, DCC, 2.) N-methyl morpholine / 1.) DMF, CH₂Cl₂, 0 deg C, 2.) CH₂Cl₂, 18 h, RT

2: 92 percent / trifluoroacetic acid / 1 h / Ambient temperature

3: 60 percent / dicyclohexylcarbodi-imide / tetrahydrofuran

4: 70 percent / 0.1M sodium hydrogen carbonate / propan-1-ol; H₂O / 18 h / Ambient temperature

With 4-methyl-morpholine; sodium hydrogencarbonate; benzotriazol-1-ol; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; propan-1-ol; water;
DOI:10.1039/P19880002647

Reference yield:

: (S)-1-{(R)-2-[((R)-5-Oxo-thiomorpholine-3-carbonyl)-amino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

: 100665-27-8
(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / dicyclohexylcarbodi-imide / tetrahydrofuran

2: 70 percent / 0.1M sodium hydrogen carbonate / propan-1-ol; H₂O / 18 h / Ambient temperature

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; propan-1-ol; water;
DOI:10.1039/P19880002647

Reference yield:

: 118903-77-8
(R)-5-oxothiomorpholin-3-ylcarbonyl-L-phenylalanyl-L-proline-t-butyl ester

: 100665-27-8
(5S,6aR,10bR,10cS)-5-Benzyl-10b-hydroxy-hexahydro-8-thia-3a,5a,10a-triaza-cyclopenta[c]fluorene-4,6,10-trione

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / trifluoroacetic acid / 1 h / Ambient temperature

2: 60 percent / dicyclohexylcarbodi-imide / tetrahydrofuran

3: 70 percent / 0.1M sodium hydrogen carbonate / propan-1-ol; H₂O / 18 h / Ambient temperature

With sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; propan-1-ol; water;
DOI:10.1039/P19880002647