(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

Base Information

Chemical Name:(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran
CAS No.:144617-42-5
Molecular Formula:C₂₈H₃₈O₂SSi
Molecular Weight:466.76
Hs Code.:

Synonyms:(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

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Chemical Property of (2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

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Technology Process of (2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

There total 6 articles about (2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₅H₇LiS

: 144617-41-4
(2S,4S)-4-(tert-Butyldiphenylsilyloxy)-1,2-epoxyhept-6-ene

: 144617-42-5
(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.166667h;

Reference yield:

: 87318-97-6
(2S)-1-[(4S)-2,2-dimethyl[1,3]dioxolan-4-yl]pent-4-en-2-ol

: 144617-42-5
(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / imidazole, 4-dimethylaminopyridine / dimethylformamide / 18 h / Ambient temperature

2: 100 percent / 80percent aq.HOAc / 8 h / Ambient temperature

3: 96 percent / 4-N,N-dimethylaminopyridine, pyridine / 6 h / Ambient temperature

4: 82 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

5: 86 percent / BF₃*OEt₂ / tetrahydrofuran / 0.17 h / -78 °C

With pyridine; 1H-imidazole; dmap; boron trifluoride diethyl etherate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 144617-60-7
(2S,4S)-4-{[1-(tert-butyl)-1,1-diphenyl]silyloxy}-6-hepten-1,2-diol

: 144617-42-5
(2'S,4'S)-6-(4-tert-Butyldiphenylsilyloxy-2-hydroxyhept-6-enyl)-3,4-dihydro-2H-thiopyran

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 4-N,N-dimethylaminopyridine, pyridine / 6 h / Ambient temperature

2: 82 percent / K₂CO₃ / methanol / 2 h / Ambient temperature

3: 86 percent / BF₃*OEt₂ / tetrahydrofuran / 0.17 h / -78 °C

With pyridine; dmap; boron trifluoride diethyl etherate; potassium carbonate; In tetrahydrofuran; methanol;