5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

Base Information

Chemical Name:5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine
CAS No.:470699-80-0
Molecular Formula:C₂₉H₄₃N₃O₈Si
Molecular Weight:589.761
Hs Code.:

Synonyms:5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

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Chemical Property of 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

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Technology Process of 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

There total 1 articles about 5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 470699-74-2
5-(4-amino-2-oxo-2H-pyrimidin-1-yl)-2-benzyloxymethyl-3-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-carboxylic acid methyl ester

: 470699-80-0
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1016/S0040-4020(02)00557-4

Reference yield: 98.0%

: 470699-80-0
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

: 470699-81-1
5'-O-benzyl-4-N-(tert-butyloxycarbonyl)-4'α-carboxyl-2'-deoxycytidine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; water;
DOI:10.1016/S0040-4020(02)00557-4

Reference yield:

: 470699-80-0
5'-O-benzyl-3'-O-(tert-butyldimethylsilyl)-4-N-(tert-butyloxycarbonyl)-2'-deoxy-4'α-methoxycarbonylcytidine

: 470699-83-3
5'-O-benzyl-4'α-[(2-(2-bromophenyl)-2-methylpropylthio)carbonyl]-4-N-(tert-butyloxycarbonyl)-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / potassium tert-butoxide / tetrahydrofuran; H₂O

2: 67 percent / BOP-Cl; triethylamine / tetrahydrofuran; CH₂Cl₂ / 2 h / Heating

With potassium tert-butylate; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/S0040-4020(02)00557-4