N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Base Information

Chemical Name:N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide
CAS No.:1395412-73-3
Molecular Formula:C₂₂H₁₄ClF₇N₂O
Molecular Weight:490.808
Hs Code.:

Synonyms:N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

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Chemical Property of N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

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Technology Process of N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

There total 3 articles about N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 1395415-62-9
N-(6-chloro-4-iodo-pyridin-3-yl)-N-methyl-3,5-bis-trifluoromethyl-benzamide

: 139911-29-8
4-fluoro-2-methylphenylboronic acid

: 1395412-73-3
N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Guidance literature:: With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,2-dimethoxyethane; water; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 785-56-8
3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride

: 1395412-73-3
N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

With sodium carbonate; lithium hexamethyldisilazane; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 825643-59-2
(6-chloro-4-iodopyridin-3-yl) methylamine

: 1395412-73-3
N-[6-chloro-4-(4-fluoro-2-methyl-phenyl)-pyridin-3-yl]-N-methyl-3,5-bis-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 °C

1.2: -78 - 20 °C

2.1: sodium carbonate / triphenylphosphine; palladium diacetate / 1,2-dimethoxyethane; water / 18 h / 90 °C / Inert atmosphere

With sodium carbonate; lithium hexamethyldisilazane; palladium diacetate; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; water;