5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Base Information

Chemical Name:5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one
CAS No.:1202803-69-7
Molecular Formula:C₂₅H₂₃ClN₂O₄
Molecular Weight:450.922
Hs Code.:

Synonyms:5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Chemical Property:

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Technology Process of 5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

There total 3 articles about 5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₆Cl₂O₂

: 18600-42-5
4-nitrobenzylamine hydrochloride

: 1202803-70-0
6-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

: 1202803-69-7
5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

: 106679-29-2
5-tert-butyl-2-(4-chlorobenzoyl)benzoic acid

: 1202803-69-7
5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2011.07.084

Reference yield:

: 32703-79-0
4-tert-butylphthalic anhydride

: 1202803-69-7
5-tert-butyl-3-(4-chlorophenyl)-3-hydroxy-2-(4-nitrobenzyl)isoindolin-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: aluminum (III) chloride / 2 h / 90 °C

2: thionyl chloride; N,N-dimethyl-formamide / tetrahydrofuran / 4 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 20 °C

With aluminum (III) chloride; thionyl chloride; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In tetrahydrofuran; 1: Friedel Crafts acylation;
DOI:10.1016/j.bmcl.2011.07.084