N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine

Base Information

• Chemical Name: N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine
• CAS No.: 1311186-24-9
• Molecular Formula: C₂₁H₂₄N₆O
• Molecular Weight: 376.461

Synonyms:N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine

Chemical Property of N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine

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Technology Process of N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine

There total 2 articles about N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazine (1211876-55-9) + m-phenylenediamine (108-45-2,64554-26-3,76583-20-5) → N1-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine (1311186-24-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at 35 ℃; for 29h;

DOI:10.1021/jm200018k

Reference yield:

4-(benzyloxy)piperidine hydrochloride → N1-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine (1311186-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 4 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 29 h / 35 °C

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1021/jm200018k

Reference yield:

N1-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine (1311186-24-9) + [2,2,2,O-3H]acetic acid → N1-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine (1311186-27-2)

Guidance literature:

[2,2,2,O-³H]acetic acid; With HATU; In N,N-dimethyl-formamide;

N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/jm200018k

upstream raw materials:

2-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazine

m-phenylenediamine

Downstream raw materials:

N₁-(4-(4-benzyloxypiperidin-1-yl)-4-chloro-1,3,5-triazin-2-yl)benzene-1,3-diamine

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