4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide
CAS No.:1415829-67-2
Molecular Formula:C₂₉H₂₂N₄O₃S
Molecular Weight:506.585
Hs Code.:

Synonyms:4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

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Chemical Property of 4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

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Technology Process of 4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

There total 6 articles about 4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1415830-54-4
8-(methylsulfonyl)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine

: 1146-43-6
N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide

: 1415829-67-2
4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

Guidance literature:: N-(4-hydroxyphenyl)-4-methylbenzenesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

8-(methylsulfonyl)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine; In N,N-dimethyl-formamide; at 100 ℃; for 16h; Inert atmosphere;
DOI:10.1016/j.bmc.2014.09.036

Reference yield:

: 613-54-7
2-Bromo-2'-acetonaphthone

: 1415829-67-2
4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate; tert-butyl alcohol / 40 h / Reflux

2.1: dimethyl sulfoxide / 16 h / 100 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C / Cooling with ice

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

4.2: 16 h / 100 °C / Inert atmosphere

With sodium hydride; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; tert-butyl alcohol; In dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1415830-52-2
8-(methylthio)-2-(naphthalen-2-yl)imidazo[1,2-a]pyrazine

: 1415829-67-2
4-methyl-N-(4-(2-(naphthalen-2-yl)imidazo[1,2-a]pyrazin-8-yloxy)phenyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 h / 20 °C / Cooling with ice

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 20 °C

2.2: 16 h / 100 °C / Inert atmosphere

With sodium hydride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide; mineral oil;