diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

Base Information

Chemical Name:diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide
CAS No.:90913-24-9
Molecular Formula:C₄₃H₃₈N₂O₆S
Molecular Weight:710.851
Hs Code.:

Synonyms:diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

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Chemical Property of diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

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Technology Process of diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

There total 5 articles about diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22252-43-3,26395-99-3,70287-30-8,72059-35-9
3-deacetyloxy-7-aminocephalosporanic acid

: 90913-24-9
diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, dimethylaniline, 2.) trimethylsilyl chloride

2: 76 percent / CH₂Cl₂ / 1 h

3: 94 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 5 °C

4: 1.) LDA / 1.) THF, hexane, HMPA, -23 deg C, 2.) THF, hexane, HMPA, -25 deg C, 3 h

With chloro-trimethyl-silane; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-Dimethylaniline; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00375a026

Reference yield:

: 76-83-5
trityl chloride

: 90913-24-9
diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N, dimethylaniline, 2.) trimethylsilyl chloride

2: 76 percent / CH₂Cl₂ / 1 h

3: 94 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 5 °C

4: 1.) LDA / 1.) THF, hexane, HMPA, -23 deg C, 2.) THF, hexane, HMPA, -25 deg C, 3 h

With chloro-trimethyl-silane; triethylamine; 3-chloro-benzenecarboperoxoic acid; 2,3-Dimethylaniline; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00375a026

Reference yield:

: 77359-81-0
7β-(tritylamino)-3-methyl-3-cephem-4-carboxylic acid

: 90913-24-9
diphenylmethyl 7β-(tritylamino)-2α-<(methoxycarbonyl)methyl>-3-methyl-3-cephem-4-carboxylate 1-oxide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / CH₂Cl₂ / 1 h

2: 94 percent / 85percent m-chloroperbenzoic acid / CH₂Cl₂ / 1 h / 5 °C

3: 1.) LDA / 1.) THF, hexane, HMPA, -23 deg C, 2.) THF, hexane, HMPA, -25 deg C, 3 h

With 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In dichloromethane;
DOI:10.1021/jm00375a026