5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane

Base Information

• Chemical Name: 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane
• CAS No.: 133043-80-8
• Molecular Formula: C₃₄H₃₄Br₄N₂O₄S₂
• Molecular Weight: 918.403
• Mol file: 133043-80-8.mol

Synonyms:5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane

Chemical Property of 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane

There total 8 articles about 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

[8,14,16-Tris-hydroxymethyl-3,11-bis-(toluene-4-sulfonyl)-3,11-diaza-tricyclo[11.3.1.15,9]octadeca-1(16),5(18),6,8,13(17),14-hexaen-6-yl]-methanol → 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane (133043-80-8)

Guidance literature:

With phosphorus tribromide; In chloroform; for 110h; Ambient temperature;

Reference yield: 75.0%

5,7,14,16-Tetrakis(acetoxymethyl)-2,11-ditosyl-2,11-diaza<3.3>metacyclophan (140410-15-7) → 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane (133043-80-8)

Guidance literature:

With hydrogen bromide; In acetic acid; for 6h; Ambient temperature;

Reference yield:

5,7,14,16-tetrakis(ethoxycarbonyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane (140410-13-5) → 5,7,14,16-tetrakis(bromomethyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane (133043-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / LiBH₄ / tetrahydrofuran / 6 h / Heating

2: 88 percent / PBr₃ / CHCl₃ / 110 h / Ambient temperature

With lithium borohydride; phosphorus tribromide; In tetrahydrofuran; chloroform;

upstream raw materials:

5,7,14,16-Tetrakis(acetoxymethyl)-2,11-ditosyl-2,11-diaza<3.3>metacyclophan

5,7,14,16-tetrakis(ethoxycarbonyl)-2,11-bis(4-tolylsulfonyl)-2,11-diaza<3.3>metacyclophane

4,6-dimethylisophthalic acid

4,6-bis(chloromethyl)-m-xylene

Downstream raw materials:

20,29,44,47-Tetrakis-(4-toluolsulfonyl)-2,11,32,41-tetrathia-20,29,44,47-tetraaza<3.3>(1,3)(1,3)<3.3>(4,6)(1,3)<3.3>(4,6)(1,3)<3.3>(4,6)(4,6)benzeno<4>phan

5,7,14,16-Tetrakis(mercaptomethyl)-2,11-bis(p-tolylsulfonyl)-2,11-diaza<3.3>metacyclophan