2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine

Base Information

• Chemical Name: 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine
• CAS No.: 335593-89-0
• Molecular Formula: C₃₆H₃₁N₅O₈
• Molecular Weight: 661.671
• Mol file: 335593-89-0.mol

Synonyms:2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine

Chemical Property of 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine

There total 3 articles about 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 2-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine (335593-88-9) → 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine (335593-89-0)

Guidance literature:

With trichlorophosphate; at 80 ℃; for 0.666667h;

DOI:10.1016/S0008-6215(01)00017-9

Reference yield:

6-hydroxy-6-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyran-3<2H,6H>-one (121701-32-4) → 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine (335593-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 96 percent / acetic acid / 2 h / 20 °C

2: 51 percent / cc. HCl / dioxane / 0.67 h / 60 °C

3: 69 percent / POCl₃ / 0.67 h / 80 °C

With hydrogenchloride; trichlorophosphate; In 1,4-dioxane; acetic acid;

DOI:10.1016/S0008-6215(01)00017-9

Reference yield:

(6S)- and (6R)-6-hydroxy-6-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyran-3-(2H,6H)iminosemicarbazone (335593-87-8) → 2-(N,N-dimethylaminomethyleneamino)-5-formyl-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine (335593-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 51 percent / cc. HCl / dioxane / 0.67 h / 60 °C

2: 69 percent / POCl₃ / 0.67 h / 80 °C

With hydrogenchloride; trichlorophosphate; In 1,4-dioxane;

DOI:10.1016/S0008-6215(01)00017-9

upstream raw materials:

N,N-dimethyl-formamide

2-amino-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine

6-hydroxy-6-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyran-3<2H,6H>-one

(6S)- and (6R)-6-hydroxy-6-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyran-3-(2H,6H)iminosemicarbazone

Downstream raw materials:

2-amino-5-cyano-7-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)pyrrolo[2,1-f][1,2,4]triazine