N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal

Base Information

• Chemical Name: N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal
• CAS No.: 158380-76-8
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434
• Mol file: 158380-76-8.mol

Synonyms:N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal

Chemical Property of N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal

There total 18 articles about N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(tert-butoxycarbonyl)-N-benzyl-L-phenylalaninol (158380-73-5) → N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal (158380-76-8)

Guidance literature:

In water; dimethyl sulfoxide; triethylamine;

Reference yield: 64.0%

(S)-2-(benzyl-tert-butoxycarbonyl-amino)-3-phenyl-propionic acid methyl ester (145654-99-5) → N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal (158380-76-8)

Guidance literature:

With diisobutylaluminium hydride; In diethyl ether; toluene; at -78 ℃; for 0.5h;

DOI:10.1016/j.tetlet.2005.05.119

Reference yield:

tert-butyl benzyl(1-(methoxy(methyl)amino)-1-oxo-3-phenylpropan-2-yl)carbamate (1325715-38-5) → N-benzyl-N-(tert-butoxycarbonyl)-L-phenylalaninal (158380-76-8)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1016/j.bmcl.2011.05.123

upstream raw materials:

N-(tert-butoxycarbonyl)-N-benzyl-L-phenylalaninol

(S)-2-(benzyl-tert-butoxycarbonyl-amino)-3-phenyl-propionic acid methyl ester

di-tert-butyl dicarbonate

(S)-2-benzylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

(1'R,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

(1'S,2'S)-2-<2-(N-benzyl-N-tert-butoxycarbonylamino)-1-hydroxy-3-phenylpropyl>-1,3-thiazole

(2S)-2-(N-benzyl-N-(tert-butoxycarbonyl)amino)-1-phenyl-3,5-heptadiene

Benzyl-((E)-(S)-1-benzyl-penta-2,4-dienyl)-carbamic acid tert-butyl ester