6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

Base Information

Chemical Name:6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one
CAS No.:664981-81-1
Molecular Formula:C₁₆H₁₄N₂O₄
Molecular Weight:298.298
Hs Code.:

Synonyms:6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

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Chemical Property of 6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

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Technology Process of 6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

There total 6 articles about 6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: benzoic acid 7-bromomethyl-3-methoxy-1-oxo-1,5,6,7-tetrahydro-pyrrolo[1,2-c]pyrimidin-5-yl ester

: 664981-81-1
6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; for 1h; Heating;
DOI:10.1055/s-2003-42112

Reference yield:

: 55878-45-0
methyl 2,6-dimethoxypyrimidine-4-carboxylate

: 664981-81-1
6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / DIBALH / CH₂Cl₂ / 4 h / -78 °C

2: 85 percent / Zn / tetrahydrofuran / 3 h / Heating

3: 85 percent / CH₂Cl₂ / 48 h / Heating

4: 82 percent / Br₂ / CHCl₃ / 4 h / 60 °C

5: 80 percent / DBU / dioxane / 1 h / Heating

With bromine; diisobutylaluminium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; zinc; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform;
DOI:10.1055/s-2003-42112

Reference yield:

: 664981-75-3
benzoic acid 1-(2,6-dimethoxy-pyrimidin-4-yl)-but-3-enyl ester

: 664981-81-1
6,7-dihydro-5-benzoyloxy-3-methoxy-7-methylenepyrrolo[1,2-c]pyrimidin-1(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Br₂ / CHCl₃ / 4 h / 60 °C

2: 80 percent / DBU / dioxane / 1 h / Heating

With bromine; 1,8-diazabicyclo[5.4.0]undec-7-ene; In 1,4-dioxane; chloroform;
DOI:10.1055/s-2003-42112