(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

Base Information

Chemical Name:(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate
CAS No.:1189569-47-8
Molecular Formula:C₃₂H₃₀F₂N₄O₄
Molecular Weight:572.611
Hs Code.:

Synonyms:(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

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Chemical Property of (2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

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Technology Process of (2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

There total 4 articles about (2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂HF₃O₂*C₃₈H₄₄F₂N₄O₅Si

: 1189569-47-8
(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

Guidance literature:: With sodium hydrogencarbonate; ethylenediamine; In water; ethyl acetate;

Reference yield:

: 957123-65-8
[(8R)-6-(tert-butoxycarbonyl)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetic acid

: 1189569-47-8
(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 4 h / 20 °C

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.5 h / 150 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 3 h

4: sodium hydrogencarbonate; ethylenediamine / water; ethyl acetate

With sodium hydrogencarbonate; ethylenediamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1189570-40-8
tert-butyl (8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-9-(2-oxo-2-{[(2R)-2'-oxo-2-{[2-(trimethylsilyl)ethoxy]methyl}-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]oxy}ethyl)-6,9-diazaspiro[4,5]decane-6-carboxylate

: 1189569-47-8
(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4,5]dec-9-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 3 h

2: sodium hydrogencarbonate; ethylenediamine / water; ethyl acetate

With sodium hydrogencarbonate; ethylenediamine; trifluoroacetic acid; In dichloromethane; water; ethyl acetate;