Technology Process of meso-(1R,4aR,5as,6aS,10S,10aS,11as,12aR)-1,10-bis(3-(2-phenylethenyl)phenyl)-octadecahydronaphthacene
There total 5 articles about meso-(1R,4aR,5as,6aS,10S,10aS,11as,12aR)-1,10-bis(3-(2-phenylethenyl)phenyl)-octadecahydronaphthacene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
O,O-diethyl benzylphosphonate;
With
sodium hydride;
In
1,2-dimethoxyethane; hexane;
at 20 ℃;
for 3h;
meso-(1R,4aR,5as,6aS,10S,10aS,11as,12aR)-1,10-bis(3-formylphenyl)-octadecahydronaphthacene;
In
1,2-dimethoxyethane; hexane;
at 20 ℃;
for 20h;
Further stages.;
DOI:10.1021/ol9913439
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1.67 g / ethanol / Raney nikel / 24 h / Heating
2.1: N-bromosuccinimide; α,α-azobisisobutyronitrile / CCl4 / 0.17 h / Heating
3.1: calcium carbonate; water / dioxane / 19 h / 20 °C
4.1: 491 mg / pyridinium chlorochromate / CH2Cl2 / 2 h / 20 °C
5.1: sodium hydride / 1,2-dimethoxy-ethane; hexane / 3 h / 20 °C
5.2: 70 percent / 1,2-dimethoxy-ethane; hexane / 20 h / 20 °C
With
N-Bromosuccinimide; ethanol; azobisisobutyronitrile; water; sodium hydride; pyridinium chlorochromate; calcium carbonate;
Raney nikel;
In
1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; hexane; dichloromethane;
1.1: Hydrogenolysis / 2.1: Bromination / 3.1: Hydrolysis / 4.1: Oxidation / 5.1: Substitution / 5.2: Condensation;
DOI:10.1021/ol9913439
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-bromosuccinimide; α,α-azobisisobutyronitrile / CCl4 / 0.17 h / Heating
2.1: calcium carbonate; water / dioxane / 19 h / 20 °C
3.1: 491 mg / pyridinium chlorochromate / CH2Cl2 / 2 h / 20 °C
4.1: sodium hydride / 1,2-dimethoxy-ethane; hexane / 3 h / 20 °C
4.2: 70 percent / 1,2-dimethoxy-ethane; hexane / 20 h / 20 °C
With
N-Bromosuccinimide; azobisisobutyronitrile; water; sodium hydride; pyridinium chlorochromate; calcium carbonate;
In
1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; hexane; dichloromethane;
1.1: Bromination / 2.1: Hydrolysis / 3.1: Oxidation / 4.1: Substitution / 4.2: Condensation;
DOI:10.1021/ol9913439
