(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

Base Information

Chemical Name:(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine
CAS No.:83537-81-9
Molecular Formula:C₁₈H₂₆N₂O₃
Molecular Weight:318.416
Hs Code.:

Synonyms:(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

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Chemical Property of (3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

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Technology Process of (3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

There total 6 articles about (3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 3587-60-8
Benzyloxymethyl chloride

: 914399-92-1
(6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: 83537-81-9
(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

Guidance literature:: (6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether; With tert.-butyl lithium; In tetrahydrofuran; at -78 ℃; for 0.166667h;

Benzyloxymethyl chloride; In tetrahydrofuran; at -78 ℃; for 4h;
DOI:10.1016/j.tetlet.2006.08.016

Reference yield:

: 914399-92-1
(6S)-6-isopropyl-5-methoxy-3-methyl-3,6-dihydro-2-pyrazinyl methyl ether

: 83537-81-9
(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

Guidance literature:: With n-butyllithium; Multistep reaction; 1) THF, -70 deg C; 2) THF;
DOI:10.1016/S0040-4020(01)91926-X

Reference yield:

: 72-18-4,25609-85-2,7004-03-7,921-10-8
L-valine

: 83537-81-9
(3R,6S)-3-[(benzyloxy)methyl]-6-isopropyl-1,4-dimethoxy-3-methyl-3,6-dihydropyrazine

Guidance literature:: Multi-step reaction with 5 steps

3: Heating

5: 1) BuLi / 1) THF, -70 deg C; 2) THF

With n-butyllithium;
DOI:10.1016/S0040-4020(01)91926-X