C₄₀H₄₇N₅O₁₀S

Base Information

Chemical Name:C₄₀H₄₇N₅O₁₀S
CAS No.:1574543-66-0
Molecular Formula:C₄₀H₄₇N₅O₁₀S
Molecular Weight:789.907
Hs Code.:

C<sub>40</sub>H<sub>47</sub>N<sub>5</sub>O<sub>10</sub>S

Synonyms:C₄₀H₄₇N₅O₁₀S

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Chemical Property of C₄₀H₄₇N₅O₁₀S

Chemical Property:

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Technology Process of C₄₀H₄₇N₅O₁₀S

There total 30 articles about C₄₀H₄₇N₅O₁₀S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1574543-78-4
C₄₀H₄₅N₅O₉S

: 1574543-66-0
C₄₀H₄₇N₅O₁₀S

Guidance literature:: With hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); In ethanol; water; at 80 ℃; for 5h;
DOI:10.1021/ol5002973

Reference yield:

: 1574543-51-3
(1S,2S,3aR,6aS)-1-(tert-butyldiphenylsilyloxy)methyl-2-methoxymethoxy-1,2,3,3a,4,6a-hexahydropentalene-1-carboxylic acid

: 1574543-66-0
C₄₀H₄₇N₅O₁₀S

Guidance literature:: Multi-step reaction with 23 steps

1.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C / Inert atmosphere

1.2: 0.17 h / -20 - 10 °C

2.1: ozone / dichloromethane; methanol / 0.08 h / -78 °C

2.2: 4 h / -78 - 20 °C / Inert atmosphere

3.1: CSA / methanol / 24 h / 20 °C / Inert atmosphere

4.1: sodium cyanoborohydride / tetrahydrofuran; formic acid / 4 h / 0 - 20 °C / Inert atmosphere

5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 - 0 °C / Inert atmosphere

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 60 °C / Inert atmosphere

6.2: 0.5 h / 60 °C / Inert atmosphere

7.1: silica gel / tetrahydrofuran; benzene / 8 h / 60 °C / Inert atmosphere

8.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran; toluene / 12 h / 60 °C / Inert atmosphere

9.1: trichlorophosphate / 1 h / 0 - 20 °C / Inert atmosphere

10.1: dmap / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

11.1: caesium carbonate; thiophenol / acetonitrile / 2 h / 0 °C / Inert atmosphere

12.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Molecular sieve; Inert atmosphere

13.1: sodium acetate; hydroxylamine hydrochloride / ethanol / 15 h / 20 °C / Inert atmosphere

14.1: acetic anhydride / 1 h / 80 °C

15.1: lithium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C

16.1: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

17.1: triethylamine / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

17.2: 1 h / 0 °C / Inert atmosphere

18.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

19.1: triethylamine / dichloromethane; water; tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

20.1: dichloromethane / 12 h / 20 °C

21.1: bromocatecholborane / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

22.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.67 h / 20 °C

23.1: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; ethanol / 5 h / 80 °C

With dmap; thionyl chloride; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); diphenyl phosphoryl azide; bromocatecholborane; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; acetic anhydride; silica gel; sodium cyanoborohydride; caesium carbonate; Dess-Martin periodane; ozone; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; formic acid; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene; 9.1: |Vilsmeier Reaction;
DOI:10.1021/ol5002973

Reference yield:

: 1574543-50-2
(1S,2S,3aR,6aS)-allyl 2-hydroxy-1-hydroxymethyl-1,2,3,3a,4,6a-hexahydropentalene-1-carboxylate

: 1574543-66-0
C₄₀H₄₇N₅O₁₀S

Guidance literature:: Multi-step reaction with 25 steps

1.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere

1.2: 12 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; pyrrolidine / acetonitrile / 3 h / 50 °C

3.1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.25 h / -30 - 20 °C / Inert atmosphere

3.2: 0.17 h / -20 - 10 °C

4.1: ozone / dichloromethane; methanol / 0.08 h / -78 °C

4.2: 4 h / -78 - 20 °C / Inert atmosphere

5.1: CSA / methanol / 24 h / 20 °C / Inert atmosphere

6.1: sodium cyanoborohydride / tetrahydrofuran; formic acid / 4 h / 0 - 20 °C / Inert atmosphere

7.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

7.2: 2 h / -78 - 0 °C / Inert atmosphere

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 60 °C / Inert atmosphere

8.2: 0.5 h / 60 °C / Inert atmosphere

9.1: silica gel / tetrahydrofuran; benzene / 8 h / 60 °C / Inert atmosphere

10.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran; toluene / 12 h / 60 °C / Inert atmosphere

11.1: trichlorophosphate / 1 h / 0 - 20 °C / Inert atmosphere

12.1: dmap / acetonitrile / 2 h / 0 - 20 °C / Inert atmosphere

13.1: caesium carbonate; thiophenol / acetonitrile / 2 h / 0 °C / Inert atmosphere

14.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 0 °C / Molecular sieve; Inert atmosphere

15.1: sodium acetate; hydroxylamine hydrochloride / ethanol / 15 h / 20 °C / Inert atmosphere

16.1: acetic anhydride / 1 h / 80 °C

17.1: lithium hydroxide / tetrahydrofuran / 2 h / 0 - 20 °C

18.1: Dess-Martin periodane / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

19.1: triethylamine / dichloromethane / 0.67 h / 0 °C / Inert atmosphere

19.2: 1 h / 0 °C / Inert atmosphere

20.1: Dess-Martin periodane / dichloromethane / 1 h / 0 °C / Inert atmosphere

21.1: triethylamine / dichloromethane; water; tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

22.1: dichloromethane / 12 h / 20 °C

23.1: bromocatecholborane / dichloromethane / 3.5 h / 0 °C / Inert atmosphere

24.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0.67 h / 20 °C

25.1: hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II) / water; ethanol / 5 h / 80 °C

With pyrrolidine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; hydrido(dimethylphosphinous acid-κP)[hydrogen bis(dimethylphosphinito-κP)]platinum(II); diphenyl phosphoryl azide; bromocatecholborane; hydroxylamine hydrochloride; tetrabutyl ammonium fluoride; sodium acetate; acetic anhydride; silica gel; sodium cyanoborohydride; caesium carbonate; Dess-Martin periodane; ozone; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; lithium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran; methanol; formic acid; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; benzene; 11.1: |Vilsmeier Reaction;
DOI:10.1021/ol5002973