2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

Base Information

Chemical Name:2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane
CAS No.:123184-88-3
Molecular Formula:C₁₇H₁₉FN₂
Molecular Weight:270.35
Hs Code.:

Synonyms:2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

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Chemical Property of 2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

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Technology Process of 2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

There total 5 articles about 2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 123184-87-2
2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-2-ethyl methanesulfonate

: 151-50-8
potassium cyanide

: 123184-88-3
2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

Guidance literature:: With potassium iodide; In water; N,N-dimethyl-formamide; for 24h; Heating;
DOI:10.1021/jm00163a005

Reference yield:

: 51594-59-3
1-(4-fluorophenyl)-2-propen-1-one

: 123184-88-3
2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

Guidance literature:: Multi-step reaction with 4 steps

1: 56 percent / Et₃N, 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride / 12 h / 70 °C

2: 84 percent / glacial acetic acid / 0.5 h / Heating

3: pyridine / 2.5 h / 0 °C

4: 88 percent / KI / dimethylformamide; H₂O / 24 h / Heating

With pyridine; 2-(2-hydroxyethyl)-3-methyl-4-benzylthiazolium chloride; acetic acid; triethylamine; potassium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a005

Reference yield:

: 123184-02-1
1-(4-Fluoro-phenyl)-5,5-dimethyl-hexane-1,4-dione

: 123184-88-3
2-<2-(4-fluorophenyl)-5-(1,1-dimethylethyl)-1H-pyrrol-1-yl>-1-cyanoethane

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / glacial acetic acid / 0.5 h / Heating

2: pyridine / 2.5 h / 0 °C

3: 88 percent / KI / dimethylformamide; H₂O / 24 h / Heating

With pyridine; acetic acid; potassium iodide; In water; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a005